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The commonest depyrogenation procedures for physical factors involve incineration and elimination by washing, also termed dilution. The literature has proven other techniques, for example filtration, irradiation and ethylene oxide cure to possess limited outcome in lessening pyrogen/endotoxin amounts.
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The exact mechanism of this phenomenon, termed endotoxin tolerance, is unidentified". Also, some reports have proven the endotoxin in the Legionnaires' bacillus has a distinct spectrum of toxicity than the more frequent gram-adverse organisms. Specifically the Legionnaires' endotoxin was not very pyrogenic (by the rabbit test), but was very Lively from the LAL - 1,000 fold difference between The 2 exams. In this example, the rabbit exam is inadequate for identifying the potency from the toxins existing.
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